A New Sesquiterpene Lactone and Other Constituents of Moquiniastrum polymorphum subsp. floccosum (Asteraceae)

Moquiniastrum polymorphum subsp floccosum extract: screening for mutagenic and antimutagenic activity.

Moquiniastrum polymorphum subsp floccosum (Cabrera) G. Sancho is used in traditional Brazilian medicine to treat inflammation and infection, which is supported by scientific data. However, only one study has been conducted on the mutagenic activity of the extract, which has important safety implications. This study evaluated the mutagenic/antimutagenic activity of M. polymorphum ethanolic extra...

Maroccanin: A New γ-lactone and Other Constituents from Centaurea maroccana Ball. (Asteraceae)

A new γ-lactone named maroccanin (1) together with 5 known compounds : scopoletin (2); 8α-[2’hydroxymethyl-2’-butenoyloxy]-dehydromelitensin (3); 11,13-dehydromelitensin (4); 8α-[2’-hydroxymethyl-2’butenoyloxy]-sonchucarpolide (5) and 5Hα,6Hβ,7Hα,-15-hydroxy-8α-(1’,2’-dihydroxyethyl-acryloxy)-elema1(2),3(4),11(13)-trien-6,12-olide (6), were isolated from the chloroform soluble part of the aqueo...

Anti-Inflammatory and Cytostatic Activities of a Parthenolide-Like Sesquiterpene Lactone from Cota palaestina subsp. syriaca

A sesquiterpene lactone 1-β,10-Epoxy-6-hydroxy-1,10H-inunolide (K100) was isolated through "bioassay-guided fractionation" from Cota palaestina subsp. syriaca, an Eastern Mediterranean endemic plant. K100 inhibited endotoxin- (ET-) induced proinflammatory markers: IL-6, MMP-9, and NO in normal mouse mammary SCp2 Cells. Molecular docking in silico suggested that K100, having highly analogous str...

The Antiinflammatory Sesquiterpene Lactone

A new sesquiterpene lactone from Artemisia rubripes nakai.

The chromatographic separation of a methylene chloride extract of Artemisia rubripes led to the isolation of a new sesquiterpene lactone (3), together with four known compounds, a coumarin (2) and three terpenes (1, 4, and 5). Their structures were characterized to be 1beta,6alpha-dihydroxy-4(15)-eudesmene (1), scopoletin (2), 1alpha,4beta-dihydroxy-8alpha-acetoxy-guaia-2,10(14), 11(13)-triene-...